Why did the following chemicals effect heart rate?!


Question: Why did the following chemicals effect heart rate.?
why did pilocarpine decrease heart rate.?

why did atropine increase heart rate.?

why did epinephrine increase heart rate.? what division of the autonomic nervous system does the addition of epinephrine imitate.?

why did digitalis decrease in heart rate.?Health Question & Answer


Answers:
Digitalis is a positive inotrope so it increases cardiac contractility and thus cardiac output. It works by inhibiting Na-K ATPase thus increasing the Na intracellulary and thus the calcium supply (this ultimately increases contractility).

Pilocarpine is a nonselective muscarinic receptor agonist. It causes bradycardia and hypotension - slows heart rate and lowers blood pressure.

Atropine is a competitive antagonist of the muscarinic acetylcholine receptors. It is used to treat bradycardia or situations of cardiac arrest. It increases the heart rate. Health Question & Answer



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