Why is the prader-Willie syndrome so serious?!
Question:
Answers:
Complications from obesity (eg, slipped capital femoral epiphyses, sleep apnea, cor pulmonale, type II diabetes mellitus) and behavioral problems are major contributors to morbidity and mortality of PWS
Patients with PWS can develop complications from the following:
1.Hypogonadism (osteoporosis/pathologic fractures)
2.Obesity arising from hyperphagia and hypometabolism (secondary to hypopituitarism) predisposes patients with this disorder to premature death from cardiorespiratory failure.
3.Slipped capital femoral epiphyses
4.Sleep apnea: Patients with PWS have a primary disturbance in central control of respiratory drive with diminished responsiveness to hypercapnia during quiet sleep.
5.Cor pulmonale
6.Diabetes mellitus type II
7.Neoplasias (eg, Wilms tumors, testicular neoplasias, endocrine [MEN 1] neoplasias, hematologic neoplasias [leukemia]) have been reported (rarely) in patients with PWS.
Answers: